Synthesis and studies of pyrazolo[3,4-b]piperidin-4-one derivatives

preliminary mlr studies of antimicrobial activity of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives

quantitative structure-activity relationship (qsar) studies of a series of substituted 3-hydroxy-pyridine-4-ones and 3-hydroxy-pyran-4-ones as antibacterial and antifungal agents against a variety of microorganisms were performed. multiple linear regression approach was used as variable selection method. the antimicrobial activities of these compounds against staphylococcus aureus, aspergilus n...

Synthesis, anti-microbial and molecular docking studies of quinazolin-4(3H)-one derivatives.

In this work, synthesis, antimicrobial activities and molecular docking studies of some new series of substituted quinazolinone 2a-h and 3a-d were described. Starting form 2-aminobenzamide derivatives 1, a new series of quinazolinone derivatives has been synthesized, in high yields, assisted by microwave and classical methods. Some of these substituted quinazolinones were tested for their antim...

Synthesis, Antimicrobial, Anticancer Evaluation and Qsar Studies of Thiazolidin-4-one Derivatives.

In this study, a novel series of 4-thiazolidinone derivatives (1-17) was synthesized and evaluated for its in vitro antimicrobial and anticancer potentials. N-(2-(5-(4-nitrobenzylidene)-2-(4-chlorophenyl)-4-oxothia- zolidin-3-ylamino)-2-oxoethyl) benzamide (7, pMICam = 1.86 µM/mL) was found to be the most active antimi- crobial agent. The anticancer study results demonstrated that N-(2-(5-(4-hy...

Chapter-8. Synthesis, antimicrobial, anticancer evaluation and QSAR studies of thiazolidin-4-one derivatives

Synthesis and antifungal bioactivities of 3-alkylquinazolin- 4-one derivatives.

A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, (1)H-NMR and (13)C-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to posse...